Ilungele ini i-Akkermansia muciniphila?

Akkermansia muciniphila i-probiotic yesizukulwane esilandelayo ethathe abacwaningi kanye nemikhiqizo yezempilo ngokufanayo ngezinzuzo zayo ezifinyelela kabanzi empilweni yabantu. Leli gciwane le-anaerobic ngokwemvelo lihlala emgudwini wesisu somuntu futhi lidlala indima ebalulekile ekugcineni ubuqotho besithiyo se-gut kanye nebhalansi ye-microbiome yonke. Ubuningi bayo buvame ukuhlotshaniswa nesisindo somzimba omncane, ukuvuvukala okuncishisiwe, nokusebenza okuthuthukisiwe kwe-metabolic. Ingaphezu kwesinye isakhamuzi samathumbu, u-Akkermansia muciniphila uqhamuke njengomdlali obalulekile emkhakheni wokudla okunempilo, ukwanelisa ukudla, kanye nokuthuthukiswa kwezidakamizwa zokwelapha. Kungakhathaliseki ukuthi ungumsunguli we-nutraceutical noma umsunguli we-skincare, ukuqonda izinzuzo zale microbe eyingqayizivele kungavula imingcele emisha ekusungulweni komkhiqizo nemiphumela yezempilo.

Ukuthuthukisa Impilo Yamathumbu: I-Akkermansia muciniphila Ikuthuthukisa Kanjani Ukugaya?

Akkermansia muciniphila iyibhaktheriya enenzuzo echuma ongqimbeni lwamafinyila olwelwesi lwamathumbu, lapho idlala indima ebalulekile ekugcineni impilo yamathumbu. Isebenza ngokukhethekile ekucekeleni phansi kwe-mucin, i-glycoprotein ebalulekile esebenza njengesithiyo esivikelayo futhi yondle ulwelwesi lwamathumbu. Ngokuphambene nokulimaza ulwelwesi lwamathumbu, umsebenzi we-Akkermansia muciniphila ukhuthaza ukuvuselelwa kwe-mucin, okuholela esivimbelweni samathumbu esinamandla, esiqinile. Le nqubo yokuvuselela ithuthukisa ubuqotho bolwelwesi lwamathumbu ngokukhuthaza ukuhlangana okuqinile phakathi kwamaseli e-epithelial, okunciphisa ukungeneka kwamathumbu. Lesi simo, esivame ukubizwa ngokuthi "amathumbu avuzayo," singaholela ezinkingeni ezihlukahlukene zezempilo lapho umgoqo wamathumbu uba sengozini.

Ngokuqinisa umgoqo we-mucosal, i-Akkermansia muciniphila isiza ukuvimbela ukungena kwamagciwane ayingozi kanye nobuthi egazini. Lesi senzo sokuzivikela sinciphisa ukuvuvukala kwesistimu, okuxhunyaniswa nezimo ezihlukahlukene zezempilo ezingapheli. Ukwengeza, ikhono lebhaktheriya lokudiliza i-mucin liholela ekukhiqizweni kwamafutha e-short chain fatty acids (SCFAs) njenge-acetate ne-propionate. Lawa ma-SCFA asebenza njengomthombo wamandla wama-colonocyte (amaseli ekholoni) futhi asize ukugcina ibhalansi ye-pH elungile emathunjini. Indawo elinganiselayo ye-pH ibalulekile ekuvimbeleni ukukhula kwamagciwane ayingozi, iqhubeke nokusekela impilo yokugaya ukudla.

Ezinkampanini ezimbonini ze-probiotic kanye ne-microbiome zokwelapha, ukufakwa kwe-Akkermansia muciniphila noma okuphuma kuyo kwe-postbiotic kunikeza indlela eqinisekisiwe ngokwesayensi yokuthuthukisa impilo yamathumbu. Kunokuba nje igcwale amathumbu ngamagciwane anenzuzo, le ndlela ithuthukisa ubuqotho besakhiwo nokusebenza kwayo yonke i-ecosystem yamathumbu, ikhuthaze uhlelo lokugaya olunempilo, olunokulinganisela.

Ukulawulwa Kwesisindo Ne-Metabolism: Ingabe Le Probiotic Ingasiza?

Ucwaningo lwakamuva luveze ukuxhumana okukhulayo phakathi Akkermansia muciniphila kanye nentuthuko empilweni ye-metabolic, ikakhulukazi maqondana nokulawulwa kwesisindo. Abantu abanamazinga aphezulu ale microbe ezuzisayo bavame ukubonisa izimpawu ezivumayo ze-metabolic, ezifana nokuncishiswa kwesiyingi sokhalo, amaphrofayili e-lipid athuthukisiwe, kanye nokuzwela kwe-insulin okuthuthukisiwe. Lokhu kuxhumana kuzuze ukunakwa okubalulekile, okwenza i-Akkermansia muciniphila igxile kakhulu ekuthuthukisweni kokudla okusebenzayo kanye nezithako ezihloselwe ukusekela impilo ye-metabolic.

Indlela eyisisekelo yalezi zinzuzo isekhonweni le-Akkermansia muciniphila lokuthonya ibhalansi yamandla kanye ne-fat metabolism. I-bacterium idlala indima ebalulekile ekulungiseni izicubu ze-adipose metabolism ngokukhiqiza ama-molecule akhombisayo asiza ukulawula i-oxidation yamafutha kanye ne-thermogenesis, izinqubo ezifaka isandla ekushiseni kwamafutha kanye nokukhiqizwa kokushisa emzimbeni. Ngaphezu kwemiphumela yayo kumetabolism yamafutha, i-Akkermansia muciniphila nayo idlala indima ebalulekile ekulawuleni ukudla. Kunomthelela ekukhiqizweni kwama-hormone afana ne-GLP-1 (i-glucagon-like peptide-1) ne-peptide YY, abambe iqhaza ekukhuthazeni imizwa yokusutha nokulawula amazinga eglucose, aqhubeke nokusekela ukuphathwa kwesisindo.

Emabhrendi emikhakheni yokulawulwa kwesisindo kanye neyokudla okunomsoco, okuhlanganisa i-Akkermansia muciniphila noma okuphuma kuyo okungenayo i-pasteurized emikhiqizweni kuveza indlela entsha yokuthuthukisa impilo kahle ye-metabolic. Kuyathakazelisa ukuthi ucwaningo luphakamisa ukuthi uhlobo lwe-pasteurized lwe-Akkermansia muciniphila lungase lube nemiphumela enamandla nakakhulu ekuthuthukiseni ukuzwela kwe-insulin uma kuqhathaniswa nobunzima obuphilayo. Lesi sici sandisa ukusetshenziswa kwaso okungase sibe khona, sinikeze indlela entsha yokuthuthukiswa kwezithasiselo eqondise isidingo esikhulayo sezixazululo zemvelo, ezisekelwa isayensi empilweni ye-metabolic.

Izinzuzo ze-Akkermansia muciniphila: Ukusuka Ekugomeni Kuya Ekulawuleni Ukuvuvukala

Ngaphandle kokugaya ukudla kanye ne-metabolism, Akkermansia muciniphila idlala indima ebalulekile ekushintshanisweni kwamasosha omzimba. Ngokuqinisa umgoqo wamathumbu kanye nokunciphisa i-endotoxemia, ithukuthelisa ngokungaqondile ukuqina kokuzivikela komzimba—okuyisisusa esiyinhloko sokuvuvukala okungapheli kanye nezimo ze-autoimmune.

Kuye kwaqashelwa ukuthi abantu abanokuphazamiseka kwe-autoimmune noma izimo zokuvuvukala okungapheli bavame ukukhombisa izinga eliphansi lale gciwane emilanjeni yabo yamathumbu. Ukwethula i-Akkermansia muciniphila kungasiza ukubuyisela ibhalansi ngokuphromotha ukuthuthukiswa kokulawula kwamaseli e-T kanye nokulungisa ukukhiqizwa kwe-cytokine. Lo mthamo we-immunomodulatory uwenza ube yisithako esithembisayo hhayi kuphela emithi yokwelapha eqondiswe emathunjini kodwa nasemikhiqizweni ye-systemic Wellness.

Konjiniyela emikhakheni ye-biomedical kanye nemithi, i-Akkermansia muciniphila imele i-biomarker kanye nokwelashwa okungaba khona kwe-adjunct yokulawula izifo ezixhumene nokuvuvukala. Umthelela wayo ku-axis ye-gut-brain futhi ikhomba ekusetshenzisweni kwe-neuroinflammation nempilo yengqondo, ivula izinkombandlela ezintsha ocwaningweni lwe-psychobiotic.

Isiphetho

Imisebenzi emangalisayo ye Akkermansia muciniphila ukunwebeka ezizindeni eziningi zezempilo-kusuka ekuthembekeni kwamathumbu kanye nokulawulwa kwe-metabolic kuya ekulinganiseni kwamasosha omzimba nokulawula ukuvuvukala. Njengoba intshisekelo yesayensi iqhubeka ikhula, namandla ayo ekubumbeni kabusha indlela esibhekana ngayo nezempilo ngokusebenzisa izixazululo ezincane. Kungakhathaliseki ukuthi usungula izithasiselo zokudla, ukudla okusebenzayo, noma ukwakheka kokwelapha, le probiotic yesizukulwane esilandelayo inikeza ithuluzi elinamandla lokuletha imiphumela elinganisekayo.

E-Guangzhou Harworld Life Sciences Co., Ltd, sisekela ukusungula kwakho ngeqembu eliqinile le-R&D, i-Synthetic Biology Superfactory, nokuzibophezela kwikhwalithi ngokukhiqiza imithombo eqondile. Sinikezela ngokwezifiso zezinto ezingavuthiwe eziguquguqukayo, ukulethwa okusheshayo, kanye nezitifiketi eziphelele ukuze sikusize ulethe imikhiqizo yakho esekwe e-Akkermansia ukuze umakethe ngokuzethemba.

Ingabe ufuna ukufunda okwengeziwe mayelana nezixazululo zethu ze-microbiome? Xhumana nathi ku admin@harworldbio.com.

Okubhekwayo

1. U-Everard, A. et al. (2013). "Inkulumo-mpikiswano phakathi kwe-Akkermansia muciniphila kanye ne-epithelium yamathumbu ilawula ukukhuluphala okubangelwa ukudla." Izinqubo zeNational Academy of Sciences.

2. Plovier, H. et al. (2017). "Iphrotheni ye-membrane ehlanzekile evela ku-Akkermansia muciniphila noma i-pasteurized bacterium ithuthukisa umzimba kumagundane akhuluphele kanye nesifo sikashukela." Umuthi Wemvelo.

3. UDao, MC et al. (2016). "I-Akkermansia muciniphila kanye nempilo ethuthukisiwe ye-metabolic ngesikhathi sokungenelela kokudla ekukhuluphaleni: ubuhlobo nokunotha kwe-gut microbiome kanye nemvelo." Amathumbu.

4. Derrien, M. et al. (2004). "I-Akkermansia muciniphila gen. nov., sp. nov., i-bacterium ehlisa isithunzi samathumbu omuntu." Ijenali yamazwe ngamazwe ye-Systematic and Evolutionary Microbiology.